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  • Asthma Medication To Treat Alzheimer’s Disease?

    by Susan November 24, 2010 at 3:51 am

    Medication currently used to inhibit proteins called 5-lipoxygenase in asthma sufferers could be used to prevent or treat Alzheimer’s Disease in the future, according to a study by Domineco Pratico. An assistant professor of pharmacology at Temple’s School of Medicine, Dr Pratico has found a link between the protein’s increase in ageing and a higher risk of Alzheimer’s.

    “What we found was 5-lipoxygenase regulates and controls the amount of total amyloid beta produced in the brain,” said Praticò. “With aging, the more 5-lipoxygenase you have the more amyloid beta you’re going to produce. This will translate into a higher risk to develop full Alzheimer’s” In a previous study, Pratico had proven that a lack of this protein alone can halve the presence of Alzheimer’s in the brain.

    Armed with this new information, it could be possible for new medication and therapies to be developed to help combat this devastating disease. Several FDA-approved 5-lipoxygenase inhibitors are currently in use for the treatment of asthma, meaning that there is no need to go through expensive drug discovery process. As the medication is approved, available and inexpensive, the only thing needed is a clinical trial to determine the effectiveness against Alzheimer’s Disease.

    As Alzheimer’s Disease curently devastates the lives of many patients and their families, any breakthrough towards preventing or curing it would surely be welcomed in the medical community. Watch this space.

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    Attacking Alzheimer’s

    by Susan July 1, 2010 at 6:54 am

    Debilitating diseases that cause progressive degeneration are not only traumatic for the patient and family, but incredibly frustrating for the medical profession as there is little we can do to halt or slow them.  A breakthrough in Alzheimer’s disease could finally open the door for scientists to begin to unlock the progress and develop new ways to combat this terminal disease that feasts on the brain, rendering the patient lost to the outside world forever.

    Using a radioactive compound was the idea of a team of scientist based at Johns Hopkins University School and the results show a clear difference in the brain scan images of healthy patients and those previously diagnosed with Alzheimer’s.  The compound, called Florbetapir, is injected into test subjects and within 30 minutes the results are starting to emerge, by 90 a full picture can be seen.  In subjects known to have a Alzheimer’s history the accumulation in the brain of the compound was significantly higher than healthy counterparts.

    Having proven reliable in all tests the safe to use compound offers a greater degree of flexibility for the physician.  It means that patients presenting with general symptoms that could potentially have one of several degenerative diseases of the brain can instantly be analyzed to see if Alzheimer’s is to blame. More importantly it allows research scientists a chance to track the progress of the disease, for the first time able to see the stages as the brain changes happen, the compound will accumulate more and in different areas as the disease progresses, and potentially this holds the key to curing, or halting the condition before complete disability has been reached.




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